Switching from Depo-Provera to Sayana Press

Sayana® Press is a contraceptive injection that contains a hormone called medroxyprogesterone acetate. This is similar to the natural hormone progesterone.

It works by stopping ovulation and thickening cervical mucus, which helps prevent pregnancy.

It provides contraception for around 13 weeks.

Medroxyprogesterone acetate is the active hormone used in both Depo‑Provera and Sayana® Press.

It is a type of medicine called a progestogen. These are similar to the natural hormone progesterone, which plays a role in the menstrual cycle.

This hormone works by stopping the release of an egg and making it less likely that sperm can reach an egg, helping to prevent pregnancy.

It is a prescription‑only medicine.

You can watch this video for a step‑by‑step guide to using Sayana® Press.

Sayana press explaination video

You will still be shown how to give the injection by a nurse before you start. If you have any questions or concerns, please contact the practice.

Sayana® Press is a very effective method of contraception.

It is more than 99% effective when used correctly and on time.

If the first injection is given within the first 5 days of your period, you will be protected straight away. If it is given at any other time, you will need to use additional contraception, such as condoms, for 7 days.

It’s important to have your injection on time.

If more than 14 weeks have passed since your last injection, you may not be protected against pregnancy. You should contact the practice as soon as possible for advice and use additional contraception in the meantime.

If you give your injection earlier than planned, this is unlikely to cause harm.

However, you may notice more side effects.

Yes, you can stop using Sayana® Press at any time.

If you plan to become pregnant, be aware that it can take some time for your fertility to return after your last injection. For some people, this can take several months or longer.

As with any medication, side effects can occur.

The most common include:

• changes to your periods (they may become lighter, irregular, or stop altogether)
• headaches
• mood changes
• abdominal discomfort

Some people find their periods become lighter or stop completely over time.

If you have any concerns about side effects, please contact the practice.

Some patients choose Sayana® Press because:

• it reduces the need to attend the surgery regularly
• it can be given at home
• it allows more control over when the injection is given
• it is a long‑acting method of contraception